Akademik Veri Yönetim Sistemi
Boz Er A. B. (Yürütücü), Er I.
Yükseköğretim Kurumları Destekli Proje, 2024 - 2025
Although the survival of patients with metastatic colon cancer that cannot be removed by surgery has been extended by nearly one year with current FDA-approved treatments, tumor progression has not been prevented. A fundamental mechanism in tumor development is the acquisition of stem cell-like potential by cancer cells. This stem cell-like behavior in tumor cells is supported by critical features of cancer, such as uncontrolled proliferation and differentiation defects. Therefore, the identification and targeting of stem cell markers in cancerous cells have the potential to slow down and even prevent colon cancer.
In this study, gene expressions activated by the Notch signaling pathway, which is involved in cell differentiation and proliferation in stem cells, will be examined using semi-quantitative PCR. Data on differential gene expressions related to stem cell characteristics between CCD841CON healthy colon cells and DLD1 cancerous colon cells will be provided. These changes in gene expression may be identified as potential therapeutic targets for future studies.