The protective effects of angiotensin-converting enzyme inhibitor against cecal ligation and puncture-induced sepsis via oxidative stress and inflammation

Kostakoglu U., Topcu A., Atak M., Tumkaya L., Mercantepe T., Uydu H. A.

LIFE SCIENCES, vol.241, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 241
  • Publication Date: 2020
  • Doi Number: 10.1016/j.lfs.2019.117051
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Cecal ligation and puncture, Inflammation, Lung, Oxidative stress, Perindopril, Rat, Sepsis, ACUTE LUNG INJURY, RESPIRATORY-DISTRESS-SYNDROME, FACTOR-KAPPA-B, TRANSCRIPTION FACTOR, CYTOKINE RELEASE, II PRODUCTION, SEPTIC RATS, PERINDOPRIL, MODEL, MECHANISMS
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Aims: Sepsis is a severe public health problem affecting millions of individuals, with global mortality rates caused by lower respiratory tract infections are approximately 2.38 million people a year die from respiratory failure caused by infection. Although ACE is known to contribute to damage in septicemia, the pathophysiological mechanisms of sepsis remain unclear. While mortality can be significantly reduced through effective and sensitive antibiotic therapy, antibiotic resistance restricts the use of these drugs, and the investigation of novel agents and targets is therefore essential. Our aim was to determine whether Perindopril (PER) has anti-inflammatory and antioxidant capable of preventing these adverse conditions resulting in injury in previous studies.