Microwave-assisted preparation of azachalcones and their N-alkyl derivatives with antimicrobial activities

Usta A., Ozturk E., Beris F. Ş.

NATURAL PRODUCT RESEARCH, cilt.28, sa.7, ss.483-487, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 7
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1080/14786419.2013.879472
  • Dergi Adı: NATURAL PRODUCT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.483-487
  • Anahtar Kelimeler: microwave synthesis, azachalcone, antimicrobial activities, N-alkyl azachalconium bromide, CHALCONES
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Two new azachalcones were prepared by both Claisen-Schmidt condensation and a simple environmentally trendy microwave-assisted method. Ten new N-alkyl (C-6,C-8,C-10,C-12,C-14)-substituted azachalconium bromides (3a-e, 4a-e) were prepared from compounds 1 and 2 with corresponding alkyl halides. The antimicrobial activities of all the compounds were tested against Enterococcus faecalis, Yersinia pseudotuberculosis, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus micro-organisms.