The relationship between severity of the disease and circulating nucleosomes in psoriasis patients

DILEK A. R. , DILEK N. , Saral Y. , YUKSEL D.

ARCHIVES OF DERMATOLOGICAL RESEARCH, vol.305, no.6, pp.483-487, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 305 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.1007/s00403-013-1347-4
  • Page Numbers: pp.483-487


Psoriasis was initially considered to represent a disease of abnormal epidermal keratinocyte proliferation. Proliferation of keratinocytes is restricted by apoptotic cell death to maintain a constant thickness of epidermis. Nucleosomes are mainly released by apoptotic cells. Tumor necrosis factor-alpha (TNF-alpha) is an important factor affecting the apoptosis. In the present study, the relationship between TNF-alpha, nucleosome and the Psoriasis Area and Severity Index (PASI) score was investigated. The patients were divided according to PASI score into three groups (mild, moderately, severe). Serum TNF-alpha and nucleosome levels were measured using Enzyme-linked immunosorbent assay (ELISA) method. Our findings show a correct relationship between PASI scores and TNF-alpha and an inverse relationship between nucleosome and PASI score. According to the results obtained from the study, we believe that serum nucleosome levels can be used as a new indicator in follow-up of patients with psoriasis and monitoring of the effectiveness of drugs which used in the treatment of psoriasis.