Effects of gadolinium-based MRI contrast agents on liver tissue

Mercantepe T. , Tumkaya L. , Celiker F. , Suzan Z. T. , Cinar S., Akyildiz K. , ...More

JOURNAL OF MAGNETIC RESONANCE IMAGING, vol.48, no.5, pp.1367-1374, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 5
  • Publication Date: 2018
  • Doi Number: 10.1002/jmri.26031
  • Title of Journal : JOURNAL OF MAGNETIC RESONANCE IMAGING
  • Page Numbers: pp.1367-1374
  • Keywords: gadodiamide, gadoteric acid, apoptosis, oxidative stress, liver, rat, OXIDATIVE STRESS, TOXICITY, CHLORIDE, RETENTION

Abstract

BackgroundPurposeMRI with contrast is often used clinically. However, recent studies have reported a high accumulation of gadolinium-based contrast agents (GBCAs) in kidney, liver, and spleen tissues in several mouse models.