Pupillometry measurement and its relationship to retinal structural changes in children with attention deficit hyperactivity disorder

Aslan M. G., Uzun F., Findik H., Kacar M., Okutucu M., Hocaoglu C.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, cilt.258, sa.6, ss.1309-1317, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 258 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s00417-020-04658-z
  • Dergi Adı: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1309-1317
  • Anahtar Kelimeler: Attention deficit hyperactivity disorder, Pupillometry, OCT, PUPILLARY LIGHT REFLEX, NERVE-FIBER LAYER, DEFICIT/HYPERACTIVITY DISORDER, MACULAR THICKNESS, ADOLESCENTS, ACCURACY, ADULTS, ADHD
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Purpose This study aims to assess the pupillometry measurements of the attention deficit hyperactivity disorder (ADHD) patients and to investigate their correlations with macular and RNFL thickness parameters by comparing the values with a healthy control group. Methods Newly diagnosed ADHD patients in a child and adolescent clinic of a tertiary hospital were consulted in an ophthalmology clinic. All participants had undergone a standard ophthalmological examination including refractometry, best corrected visual acuity, color vision, anterior segment biomicroscopy, fundoscopy, pupillometry, and OCT. All results were compared with a healthy control group at the same age. Results The study group consisted of 32 patients and there were 43 children in the control group. Mean pupillary velocities of ADHD patients and control group were 0.60 +/- 0.11 mm/s and 0.63 +/- 0.11 mm/s, and 0.49 +/- 0.12 mm/s and 0.50 +/- 0.10 mm/s, for right and left eyes, respectively. The difference was statistically significant for both eyes (p < 0.05). Mean RNFL thickness measurements of the study group were 90.69 +/- 8.58 mu m and 89.63 +/- 8.14 mu m for right and left eyes, respectively and those were 87.35 +/- 7.67 mu m and 88.77 +/- 7.44 mu m, respectively in the healthy group. Correlation between right pupillary velocity and RNFL thickness was statistically significant (r = 0.339, p = 0.003). Conclusion Higher pupillary velocity values were observed in both eyes of children with ADHD and that was positively correlated with RNFL measurements of their right eyes.