The protective role of fosfomycin in lung injury due to oxidative stress and inflammation caused by sepsis

Yildiz İ. E., Topcu A., Bahceci İ., Arpa M., Tumkaya L., Mercantepe T., ...More

LIFE SCIENCES, vol.279, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 279
  • Publication Date: 2021
  • Doi Number: 10.1016/j.lfs.2021.119662
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Fosfomycin, Inflammation, Lung, Oxidative stress, Rat, Sepsis, CECAL LIGATION, RATS
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Aim: Early and prompt treatment of sepsis by effective antibiotics against susceptible organisms may be lifesaving. However, increased antibiotic resistance and side effects of chemotherapeutic agents limiting their tolerability result in a restricted use of medications. This has led to an increased search for solution oriented novel treatments and therapeutic targets, as well as investigations on the pathogenesis and physiology of sepsis. In this study, we aimed to examine the antioxidant and anti-inflammatory effects of fosfomycin in sepsis resulting from other causes. Main methods: Sprague Dawley rats were assigned into three groups. Randomly selected control rats received intraperitoneal saline solution only. Only caecal puncture and ligation were carried out in the caecal ligation and puncture (CLP) group, while in the CLP + fosfomycin group (CLP + FOS), together with sepsis due to caecal puncture and ligation, 500 mg/kg of FOS was administered intraperitoneally (i.p.).