Synthesis of Some Novel 1,2,4-Triazol-3-one Derivatives Bearing the Salicyl Moiety and Their Anticonvulsant Activities

KAHVECİ B., Mentese E., AKKAYA E., Yilmaz F., DOĞAN İ. S., ÖZEL A.

ARCHIV DER PHARMAZIE, cilt.347, sa.6, ss.449-455, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 347 Sayı: 6
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1002/ardp.201300427
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.449-455
  • Anahtar Kelimeler: Anticonvulsant activity, Microwave irradiation, Salicyl aldehyde, Triazol-3-one, MICROWAVE-ASSISTED SYNTHESIS, ANTIFUNGAL ACTIVITY, TOXICITY
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

A series of new 1,2,4-triazole-3-one derivatives bearing the salicyl moiety were synthesized by using microwave irradiation, and their chemical structures were identified by IR, H-1 NMR, C-13 NMR, elemental analysis, and LC-MS. The anticonvulsant activities of the compounds 4a-c, 4e, and 5a-e were evaluated by the Anticonvulsant Screening Program of the National Institute of Health, USA. The compounds had moderate anticonvulsant activities in the maximum electroshock-induced seizure and minimal clonic seizure models in mice, without any neurotoxic effects.