Serum apelin levels and cardiovascular diseases Serum Apelin Düzeyleri ve Kardiyovasküler Hastalıklar

Aşkın L., Askin H. S., tanrıverdi o., Özyıldız A. G., DUMAN H.

Northern Clinics of Istanbul, cilt.9, sa.3, ss.290-294, 2022 (ESCI) identifier identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 9 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.14744/nci.2021.33427
  • Dergi Adı: Northern Clinics of Istanbul
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Central & Eastern European Academic Source (CEEAS), Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.290-294
  • Anahtar Kelimeler: Apelin, cardiomyocytes, inotropy, myocardial performance, PEPTIDE APELIN, CARDIAC-FUNCTION, HEART, APJ, CONTRACTILITY, SUSCEPTIBILITY, LOCALIZATION, POLYMORPHISM, PROGRESSION, MECHANISMS
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Apelin is a G protein-linked receptor endogenous ligand, synthesized as a 77-amino acid pre-propeptide. Increased expression of apelin is present in many cardiovascular (CV) tissues, including cardiomyocytes. It is a peripheral vasodilator and one of the most potent stimulants of ventricular contraction. Apelin may be a valuable therapeutic for both blood pressure regulation and myocardial performance. More information is needed for the CV pathophysiology of apelin. We will discuss the importance of apelin level in CV diseases in this review.