The effect of hesperidin and quercetin on oxidative stress, NF-kappa B and SIRT1 levels in a STZ-induced experimental diabetes model


İSKENDER H., DOKUMACIOĞLU E., Sen T. M. , Ince I., KANBAY Y., Saral S.

BIOMEDICINE & PHARMACOTHERAPY, vol.90, pp.500-508, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 90
  • Publication Date: 2017
  • Doi Number: 10.1016/j.biopha.2017.03.102
  • Journal Name: BIOMEDICINE & PHARMACOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.500-508
  • Keywords: Diabetes, Hesperidin, NF-kappa B, Oxidative stress, Quercetin, Sirtuin-1, FLAVONOID ANTIOXIDANT, NEPHROPATHY, INHIBITION, BETA, RATS, HYPERGLYCEMIA, TRANSCRIPTION, ACTIVATION, PREVENTS, LIVER
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Objective: The aim of this study is to investigate the roles of SIRT1 and NF-kappa B in the pathogenesis of diabetes mellitus in rats with STZ-induced diabetes and determine the effects of hesperidin and quercetin on oxidative stress and on the levels of SIRT1 and NF-kappa B.