Effect of Infliximab on Renal Injury Due to Methotrexate in Rat

KIRBAS A., Cure M. C., Kalkan Y., Cure E., TÜMKAYA L., Sahin O. Z., ...Daha Fazla

IRANIAN JOURNAL OF KIDNEY DISEASES, cilt.9, sa.3, ss.221-229, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 3
  • Basım Tarihi: 2015
  • Dergi Adı: IRANIAN JOURNAL OF KIDNEY DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.221-229
  • Anahtar Kelimeler: methotrexate, infliximab, nephrotoxicity, carbonic anhydrase, adenosine deaminase, ADENOSINE-DEAMINASE ACTIVITY, CARBONIC-ANHYDRASE-II, NITRIC-OXIDE, REPERFUSION, EXTRACT, DAMAGE, LEVEL, MALONDIALDEHYDE, EXPRESSION, REDUCTION
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Introduction. Methotrexate, an antagonist of folic acid used in the treatment of many cancers and inflammatory diseases, is associated with side effects that limit its usage. Infliximab has been reported to have a protective effect against nephrotoxicity induced by some drugs and ischemic reperfusion. We aimed to investigate whether infliximab has a protective effect against methotrexate-induced nephrotoxicity.