Microwave-assisted synthesis and investigation of xanthine oxidase inhibition of new phthalonitrile and phthalocyanines containing morpholino substituted 1,2,4-triazole-3-one

KANTAR G. K., BALTAS N., MENTESEE E., Sasmaz S.

JOURNAL OF ORGANOMETALLIC CHEMISTRY, cilt.787, ss.8-13, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 787
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.jorganchem.2015.03.033
  • Dergi Adı: JOURNAL OF ORGANOMETALLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.8-13
  • Anahtar Kelimeler: Phthalocyanine, Microwave-synthesis, Triazole, Morpholino, Xanthine oxidase, ANTIMICROBIAL ACTIVITY, METALLO-PHTHALOCYANINES, ANTICANCER ACTIVITY, ANALGESIC ACTIVITY, DERIVATIVES, ANTIBACTERIAL, MOIETY, ACID, IRRADIATION, FLAVONOIDS
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Novel phthalonitrile and zinc (II) phthalocyanines containing pharmacological active molecules like morpholine and triazole were prepared and characterized. The new compounds were obtained by both microwave assisted and conventional method. The structure of compounds were characterized by elemental analysis, IR, UV/vis, H-1 NMR, C-13 NMR and Mass spectroscopy techniques. All compounds were screened for anti-xanthine oxidase (anti-XO) activities. The compound 3 showed promising XO inhibition with IC50 value as 0.082 +/- 0.004 mM. Phthalocyanine compounds did not show XO inhibition due to high aggregation tendency and low solubility. (C) 2015 Elsevier B.V. All rights reserved.