The role of the adhesion molecule Nectin-4 in the pathogenesis of endometriosis

Bedir R., Sehitoglu I., Balik G., KAGITCI M., Gucer H., YURDAKUL C., ...More

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, vol.43, no.3, pp.463-466, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.12891/ceog2150.2016
  • Journal Name: CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.463-466
  • Keywords: Endometriosis, Nectin-4, Immunohistochemistry, EUTOPIC ENDOMETRIUM, DIFFERENT PROFILE, TISSUES EXPRESS, OVARIAN, CANCER, PERITONEAL
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Objective: Nectins are immunoglobulin-like adhesion molecules, and they play important role in cell proliferation and tumor metastasis. The objective in this study was to compare the expression of Nectin-4 in normal endometrium and in ectopic endometriotic tissues. Materials and Methods: Nectin-4 expression was investigated in ovarian endometriosis (n=20), peritoneal endometriosis (n=20), endometrium of endometriosis (n=20), and in a control group (having no endometriosis) (n=20) by immunohistochemical method. Results: Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis (p = 0.003 andp = 0.009, respectively). This difference was significant in the endometrium of patients having endometriosis (p = 0.011). Conclusion: The authors believe that Nectin-4 molecule may contribute to the pathogenesis of endometriosis. For this reason, the use of medicines developed against this molecule in the treatment of endometriosis may be useful.