Epicardial adipose tissue is associated with increased systolic pulmonary artery pressure in patients with chronic obstructive pulmonary disease

Kalaycıoğlu E., Çetin M., Çinier G., Özyıldız A. G., Durmuş İ., Kırış T., ...Daha Fazla

Clinical Respiratory Journal, cilt.15, sa.4, ss.406-412, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1111/crj.13316
  • Dergi Adı: Clinical Respiratory Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.406-412
  • Anahtar Kelimeler: chronic obstructive pulmonary disease, epicardial adipose tissue, pulmonary hypertension, systolic pulmonary arterial pressure, XANTHINE-OXIDASE, ENDOTHELIAL DYSFUNCTION, COPD, HYPERTENSION, FAT, STANDARDS, DIAGNOSIS
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Objectives: Pulmonary hypertension (PHT) is one of the essential predictors of mortality in chronic obstructive pulmonary disease (COPD). It is thought that PHT is due to vasoconstriction secondary to hypoxia caused by airway obstruction in COPD patients; however, loss of capillary bed with emphysema, inflammation, and endothelial dysfunction may also play a role in the development of PHT. Epicardial adipose tissue (EAT) has a role as a metabolically active endocrine organ and secretes various proinflammatory cytokines. We hypothesized that EAT thickness in COPD patients might be associated with the systolic pulmonary arterial pressure (PAPs) level, and we aimed to test it. Methods: The present study included 129 consecutive patients with the diagnosis of COPD. All patients underwent transthoracic echocardiographic evaluation. The relationship between PAPs and EAT thickness was evaluated. Results: Positive correlations with PAPs were reported with age, EAT, white blood cell (WBC) and GOLD grade score (range 0.197-0.275, P values 0.026 to 0.002), negative correlations with body-mass index (BMI), hyperlipidemia, FEV1 (% predicted) and pO2 (range −0.216 to −0.340, P values.014 to <.001). In stepwise linear regression analysis, BMI (P =.003), EAT (P =.002), WBC (P =.001), and FEV1 (% predicted) (P =.010), were independently associated with PAPs. Conclusion: EAT thickness in COPD patients with preserved left ventricular systolic function is associated with increased PAPs, and this association is independent of the parameters indicating the severity of COPD.