GLOBAL STABILITY IN A PATHOGEN-SPECIFIC CD8 IMMUNE RESPONSE PREDICTION MODEL

Anac H., MERDAN M., Bekiryazici Z.

SIGMA JOURNAL OF ENGINEERING AND NATURAL SCIENCES-SIGMA MUHENDISLIK VE FEN BILIMLERI DERGISI, cilt.10, sa.3, ss.325-342, 2019 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 3
  • Basım Tarihi: 2019
  • Dergi Adı: SIGMA JOURNAL OF ENGINEERING AND NATURAL SCIENCES-SIGMA MUHENDISLIK VE FEN BILIMLERI DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.325-342
  • Anahtar Kelimeler: CD8 T-Cell immunity response, local stability, global stability, equilibrium, persistence, INFECTION
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

In this study, a system of ordinary differential equations used for modeling pathogen-specific CD8 cell immune response is studied. The positivity and the limitation of the model solutions are proven. The equilibrium points in the cases with the presence and the absence of the pathogen are determined and their stabilities are investigated. Furthermore, the essential reproduction number is obtained for the system. The conditions of the reproduction number for the stability of the equilibrium are shown and numerical examples are given for supporting the analytical results.