Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers

HALICI, Zekai; Polat, Beyzagul; ÇADIRCI, Elif; Topcu, ATİLLA; Karakus, Emre; KÖSE, Duygu; ALBAYRAK, Abdulmecit; BAYIR, Yasin

doi:10.1016/j.cbi.2016.09.011

Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers

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HALICI Z., Polat B., ÇADIRCI E., Topcu A., Karakus E., KÖSE D., ...More

CHEMICO-BIOLOGICAL INTERACTIONS, vol.258, pp.266-275, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 258
Publication Date: 2016
Doi Number: 10.1016/j.cbi.2016.09.011
Journal Name: CHEMICO-BIOLOGICAL INTERACTIONS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.266-275
Keywords: Aliskiren, Cytokine, Indomethacin, Renin angiotensin aldestron system, Ulcer, SMOOTH-MUSCLE-CELLS, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, OXIDATIVE STRESS, RECEPTOR ANTAGONIST, INDUCED LESIONS, MUCOSAL DAMAGE, NITRIC-OXIDE, INFLAMMATION, TELMISARTAN, PROTECTS
Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Purpose: Previously blocking the renin angiotensin system (RAAS) has been effective in the prevention of gastric damage. Therefore, the aim of this study was to investigate the effects of aliskiren, and thus, direct renin blockage, in indomethacin-induced gastric damage model.