Reversal of neuromuscular blockade with sugammadex or neostigmine/atropine: Effect on postoperative gastrointestinal motility

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Sen A., Erdivanli B., Tomak Y., Pergel A.

JOURNAL OF CLINICAL ANESTHESIA, vol.32, pp.208-213, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32
  • Publication Date: 2016
  • Doi Number: 10.1016/j.jclinane.2016.03.010
  • Journal Name: JOURNAL OF CLINICAL ANESTHESIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.208-213
  • Keywords: Neuromuscular agents, Sugammadex, Neostigmine, Postoperative period, Constipation, ACUTE COLONIC PSEUDOOBSTRUCTION, LAPAROSCOPIC SURGERY, ILEUS, ANESTHESIA, RECOVERY, TRIAL, AGENT, CARE
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Study objective: To compare sugammadex with conventional reversal of neuromuscular block in terms of postoperative gastrointestinal motility.

Design: Double blinded, randomized, controlled clinical trial.

Setting: Operating room, postoperative recovery area.

Patients: Seventy-two patients with ASA physical status I or II, scheduled for total thyroid surgery were studied.

Interventions: When 4 twitches were observed on train-of-four stimulation, neuromuscular block was reversed conversatively in the control group, and with sugammadex in the study group.

Measurements: Time to first flatus and feces, incidence of postoperative nausea, vomiting, diarrhea and constipation were collected.

Main results: Median time of first flatus was 24 hours (18-32 [10-36]) in the neostigmine group, and 24 (18-28 [12-48]) in the sugammadex group (P > .05). Median (IQR) time of first feces was 24 hours (18-36 [10-48]) in neostigmine group, 32 hours (28-36 [12-72]) in sugammadex group (P > .05). There were no occurrences of nausea, vomiting, diarrhea, or constipation.

Conclusions: Sugammadex may be safely used in cases where postoperative ileus is expected.

Study objective: To compare sugammadex with conventional reversal of neuromuscular block in terms of postoperative gastrointestinal motility.