Effects of 900 MHz electromagnetic field on prenatal locomotor development in rats


Balik M. S., Tumkaya L., Sehitoglu I., Kalkan Y., Yilmaz A., Balik G., ...More

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol.12, no.3, pp.2364-2373, 2019 (SCI-Expanded) identifier

Abstract

Introduction: The present study investigated the effects of 900 MHz electromagnetic field (EMF) on locomotor system development in pregnant rats. Materials and methods: Following impregnation, the rats were divided into a study group (exposure to 900 MHz EMF) and control group (no exposure). A total of 28 rat pups were used in the study. On the 60th postnatal day, bone, nerve, and muscle tissues were evaluated by radiological, biochemical, and histological methods. Results: The study group showed significantly decreased femoral medullary canal diameter to cortical thickness ratio (15.3% in females, 8.5% in male pups, p<0.05), lower alkaline phosphatase levels (18.24% in females, p>0.05. 22.25% in male pups, p<0.05), and higher calcium (2.37% in females, 0.09% in male pups, p>0.05) and creatinine kinase levels (16.86% in females, 3.01% in male pups, p>0.05). Neuronal nitric oxide synthase (nNOS) immunoreactivity of sciatic nerve tissues and calcineurine staining of bone tissues indicated significantly higher anti-nNos and anti-calcineurin a antibody levels in the study group (p<0.05). Conclusion: Prenatal exposure of rat pups to 900 MHz EMF may negatively affect the development of sciatic nerves, muscles, and bones.