Immunolocalization of ERK1/2 and p-AKT in normal endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer and their prognostic significance in malignant group


Gungorduk K., Ertas I. E., Sahbaz A., Ozvural S., Sarica Y., Ozdemir A., ...More

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, vol.179, pp.147-152, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 179
  • Publication Date: 2014
  • Doi Number: 10.1016/j.ejogrb.2014.05.040
  • Journal Name: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.147-152
  • Keywords: Endometrial hyperplasia, Endometrioid endometrial adenocancer, ERK1/2, p-AKT, Immunolocalization, Prognosis, ESTROGEN-RECEPTOR-ALPHA, SIGNALING PATHWAY, KINASE, CANCER, ACTIVATION, CARCINOMA, PHOSPHORYLATION, PROLIFERATION, INHIBITION, SURVIVAL
  • Recep Tayyip Erdoğan University Affiliated: No

Abstract

Objective: To analyze the expression patterns of extracellular signal-regulated kinase (ERK1/2) and phosphorylated (p)-AKT in the tissues of non-pathologic endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer using indirect immunohistochemistry, and also to investigate the effect of ERK1/2 and p-ART expression patterns on prognosis in endometrioid adenocancer.