Immunolocalization of ERK1/2 and p-AKT in normal endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer and their prognostic significance in malignant group

Gungorduk, Kemal; Ertas, Ibrahim; Sahbaz, Ahmet; Ozvural, Seyfettin; Sarica, Yagmur; Ozdemir, Aykut; Sayhan, Sevil; Gokcu, Mehmet; Yilmaz, BÜLENT; Sanci, Muzaffer; Inan, Sevinc; Harma, Mehmet; Yildirim, Yusuf

doi:10.1016/j.ejogrb.2014.05.040

Immunolocalization of ERK1/2 and p-AKT in normal endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer and their prognostic significance in malignant group

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Gungorduk K., Ertas I. E., Sahbaz A., Ozvural S., Sarica Y., Ozdemir A., ...More

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, vol.179, pp.147-152, 2014 (SCI-Expanded)

Publication Type: Article / Article
Volume: 179
Publication Date: 2014
Doi Number: 10.1016/j.ejogrb.2014.05.040
Journal Name: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.147-152
Keywords: Endometrial hyperplasia, Endometrioid endometrial adenocancer, ERK1/2, p-AKT, Immunolocalization, Prognosis, ESTROGEN-RECEPTOR-ALPHA, SIGNALING PATHWAY, KINASE, CANCER, ACTIVATION, CARCINOMA, PHOSPHORYLATION, PROLIFERATION, INHIBITION, SURVIVAL
Recep Tayyip Erdoğan University Affiliated: No

Abstract

Objective: To analyze the expression patterns of extracellular signal-regulated kinase (ERK1/2) and phosphorylated (p)-AKT in the tissues of non-pathologic endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer using indirect immunohistochemistry, and also to investigate the effect of ERK1/2 and p-ART expression patterns on prognosis in endometrioid adenocancer.