Immunolocalization of ERK1/2 and p-AKT in normal endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer and their prognostic significance in malignant group

Gungorduk, Kemal; Ertas, Ibrahim; Sahbaz, Ahmet; Ozvural, Seyfettin; Sarica, Yagmur; Ozdemir, Aykut; Sayhan, Sevil; Gokcu, Mehmet; Yilmaz, BÜLENT; Sanci, Muzaffer; Inan, Sevinc; Harma, Mehmet; Yildirim, Yusuf

doi:10.1016/j.ejogrb.2014.05.040

Immunolocalization of ERK1/2 and p-AKT in normal endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer and their prognostic significance in malignant group

Gungorduk K., Ertas I. E., Sahbaz A., Ozvural S., Sarica Y., Ozdemir A., ...Daha Fazla

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, cilt.179, ss.147-152, 2014 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 179
Basım Tarihi: 2014
Doi Numarası: 10.1016/j.ejogrb.2014.05.040
Dergi Adı: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.147-152
Anahtar Kelimeler: Endometrial hyperplasia, Endometrioid endometrial adenocancer, ERK1/2, p-AKT, Immunolocalization, Prognosis, ESTROGEN-RECEPTOR-ALPHA, SIGNALING PATHWAY, KINASE, CANCER, ACTIVATION, CARCINOMA, PHOSPHORYLATION, PROLIFERATION, INHIBITION, SURVIVAL
Recep Tayyip Erdoğan Üniversitesi Adresli: Hayır

Özet

Objective: To analyze the expression patterns of extracellular signal-regulated kinase (ERK1/2) and phosphorylated (p)-AKT in the tissues of non-pathologic endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer using indirect immunohistochemistry, and also to investigate the effect of ERK1/2 and p-ART expression patterns on prognosis in endometrioid adenocancer.