Design and microwave-assisted synthesis of a novel Mannich base and conazole derivatives and their biological assessment

Cebeci Y. U., ALPAY KARAOĞLU Ş.

HETEROCYCLIC COMMUNICATIONS, cilt.27, sa.1, ss.100-111, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1515/hc-2020-0126
  • Dergi Adı: HETEROCYCLIC COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Directory of Open Access Journals
  • Sayfa Sayıları: ss.100-111
  • Anahtar Kelimeler: 1,2,4-triazole, fluoroquinolone, conazole, anti-microbial activity, ANTIMICROBIAL ACTIVITY EVALUATION, SCHIFF-BASES, 1,2,3-TRIAZOLE DERIVATIVES, ANTIVIRAL ACTIVITY, POSACONAZOLE, ANTIOXIDANT, HETEROCYCLES, PYRAZOLE
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

4-Amino-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (1) was converted to the corresponding Schiff base (2) by treatment with salicylaldehyde. 1,2,4-Triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-component procedure. Moreover, the synthesis of six compounds, which can be considered as conazole analogues, was performed starting from 1,2,4-triazole-3-one compounds via three steps by either conventional or microwave-mediated conditions. All the newly synthesized compounds were screened for their antimicrobial activities. Most exhibited good to moderate antibacterial and/or antifungal activity. The structural assignments of the new compounds were based on elemental analysis and spectral (IR, H-1 NMR, C-13 NMR, and LC-MS) data.