Synthesis, potentiometric titrations and antioxidant activities of some 4-acylamino-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives

Yuksek H., Alkan M., Islamoglu F. , Bahceci S., Elmastas M., Calapoglu M., ...Daha Fazla

ASIAN JOURNAL OF CHEMISTRY, cilt.20, sa.7, ss.5311-5321, 2008 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Konu: 7
  • Basım Tarihi: 2008
  • Sayfa Sayıları: ss.5311-5321


Five novel 3-alkyl-4-cinnamoylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (I)with cinnamoyl chloride and characterized by elemental analyses and IR,(1)H NMR, (13)C NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, t-butyl alcohol, acetonitrile and N,N-dimethylformamide and the half-neutralization potential values and the corresponding pK(a) values were determined for all cases. In addition, these new compounds (except compound 2a) and five recently reported 3-alkyl-4-isobutyrylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were screened for their antioxidant activities.