Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level

ULUSOY Ş., Ozkan G., MENTEŞE A., Yavuz A., KARAHAN S. C. , Sumer A.

CLINICAL BIOCHEMISTRY, vol.45, pp.1444-1449, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45
  • Publication Date: 2012
  • Doi Number: 10.1016/j.clinbiochem.2012.07.103
  • Title of Journal : CLINICAL BIOCHEMISTRY
  • Page Numbers: pp.1444-1449


Background: Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)domain-containing protein 1 (SCUBE1) is a cell surface protein belonging to the SCUBE gene family. SCUBE1 has been shown to rise in parallel with platelet activation in acute ischemic events. However, there are no studies showing levels in the hemodialysis patient group, in which there is known to be an increase in platelet function impairment and activation. The purpose of this study was to investigate SCUBE1 levels in a hemodialysis patient group and the factors affecting those levels.