The Activity of Adenosine Deaminase and Dipeptidyl Peptidase IV in Children With Attention Deficit Hyperactivity Disorder

NARALAN Y. S., DOĞAN Ö., ELGÜN ÜLKAR S., ÖZTOP D. B., KILIÇ TÜLÜ B.

Journal of Attention Disorders, cilt.28, sa.1, ss.25-30, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1177/10870547231197212
  • Dergi Adı: Journal of Attention Disorders
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, CINAHL, MEDLINE, Psycinfo
  • Sayfa Sayıları: ss.25-30
  • Anahtar Kelimeler: ADA, attention deficit hyperactivity disorder, child, DPP IV
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Objective: In this study, to investigate the place of T cell-mediated immunity in the etiology of ADHD, for which we do not have enough information; we aimed to investigate the activity of DPP IV and ADA, which are T cell-related enzymes, and the relationship of these enzymes with ADHD symptoms in children with ADHD. Methods: Twenty-seven children aged 6 to 12 years with a diagnosis of attention deficit hyperactivity disorder and 27 children aged 6 to 12 years without any psychiatric disease were included in the study. Results: While serum ADA and DPP-IV activity were found to be statistically significantly higher in the group with ADHD. There was no statistically significant correlation between serum ADA and DPP-IV activities and CTRS-R-L and CPRS-R-L in both groups. Conclusion: We think that T cell mediated inflammation may play a role in the etiology of ADHD due to changes in ADA and DPP-IV levels in children.