Involvement of Metabolites and Non-coding RNAs in Diseases

Coskun K. A., Kıyak B. Y., Cifci K. U., Kadioglu E., Yurekli N., TUTAR Y.

Current Pharmaceutical Biotechnology, cilt.24, sa.7, ss.889-912, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 24 Sayı: 7
  • Basım Tarihi: 2023
  • Doi Numarası: 10.2174/1389201023666220921091240
  • Dergi Adı: Current Pharmaceutical Biotechnology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.889-912
  • Anahtar Kelimeler: disease, Metabolism, metabolite analysis, metabolites, non-coding, RNAs
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Hayır

Özet

Non-coding RNAs have a role in gene regulation and cellular metabolism control. Metabolism produces metabolites which are small molecules formed during the metabolic process. So far, a direct relationship between metabolites and genes is not fully established; however, pseudogenes and their progenitor genes regulate health and disease states. Other non-coding RNAs also contribute to this regulation at different cellular processes. Accumulation and depletion of metabolites accompany the dynamic equilibrium of health and disease state. In this study, metabolites, their roles in the cell, and the link between metabolites and non-coding RNAs are discussed.