Effects of infliximab against carbon tetrachloride-induced spleen toxicity in rats

Bahcecı I., Tumkaya L., Mercantepe T., Yılmaz H., Ibık Y. E., Duran O. F., ...More

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.27, no.3, pp.1140-1146, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.26355/eurrev_202302_31220
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Page Numbers: pp.1140-1146
  • Keywords: Carbon tetrachloride, CD3, CD68, CD200R, Spleen, LIVER, METHOTREXATE, APOPTOSIS, INJURY
  • Recep Tayyip Erdoğan University Affiliated: Yes


OBJECTIVE: Carbon tetrachlo-ride (CCl4) is a non-polar molecule used in indus-try in grain curing, insect-killing and especially in the production of chlorofluorocarbons. It is esti-mated that an average of 70,000 industry workers in Europe are exposed to this toxic compound.MATERIALS AND METHODS: Twenty-four male Sprague-Dawley rats were randomly allo-cated into four groups: control group (saline on-ly, Group I), infliximab (INF) group (Group II), CCl4 group (Group III) and CCl4+INF group (Group IV).RESULTS: While there was an increase in the numerical density of CD3, CD68, and CD200R positive T lymphocytes and macrophages in the CCl4 administration group (p=0.000), this was not the case in the CCl4+INF administration group (p=0.000).CONCLUSIONS: TNF-alpha inhibitors have a pro-tective effect against CCl4-induced spleen tox-icity/inflammation as seen by the reduction in CD3, CD68, CD200R positive T lymphocytes and macrophages.