Akademik Veri Yönetim Sistemi
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2025 (SCI-Expanded)
In this work, 13 novel ciprofloxacin hybrid molecules containing active groups such as coumarin, triazole, pyridine, and benzimidazole were designed, synthesized, and screened for their antibacterial activities against Gram-positive (B. megaterium, B. subtilis, E. faecalis, and S. aureus) and Gram-negative (E. coli, P. aeruginosa, E. cloacae, Y. pseudotuberculosis, and S. typhimurium) bacteria. The obtained results demonstrated that the general synthesized compounds showed similar or better activities than the standard drug ciprofloxacin. The structure-activity relationship (SAR) studies have showed that the combination of benzimidazole, azabenzimidazole, triazole, and coumarin moieties with ciprofloxacin increased the antibacterial activities against most of the tested microorganisms. The characterization studies were done by using IR, 1H-NMR, 13C-NMR, LC-MS/MS, and elemental analysis technique.