The risk of development of primary biliary cholangitis among incidental antimitochondrial M2 antibody-positive patients

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Hepatology forum, vol.4, no.2, pp.69-73, 2023 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 2
  • Publication Date: 2023
  • Doi Number: 10.14744/hf.2023.2023.0016
  • Journal Name: Hepatology forum
  • Journal Indexes: TR DİZİN (ULAKBİM)
  • Page Numbers: pp.69-73
  • Recep Tayyip Erdoğan University Affiliated: Yes


Background and Aim: This study investigated the risk of the development of primary biliary cholangitis (PBC) in individuals who were incidentally identified as having positive antimitochondrial antibodies (AMA)-M2. Materials and Methods: We retrospectively reviewed extractable nuclear antibody (ENA) panel test results to identify the incidental AMA-M2- positive patients. Patients who filled the diagnostic criteria for PBC were excluded. AMA-M2-positive patients were further evaluated by physical examination, liver biochemistry, liver ultrasonography, and transient elas tography (TE) and were also closely followed. Results: We included 48 (n=45, 93% female) individuals with a median age of 49 (range: 20–69) years. The median follow-up duration was 27 months (range: 9–42) after the detection of AMA-M2. Thirty-three (69%) patients had concomitant autoimmune/inflammatory disorders. Twenty-eight (58%) individuals showed seropositivity for ANA, and 21 had (43%) positive AMA. Fifteen (31%) patients developed typical PBC according to the international PBC diagnostic criteria during the follow-up, and five of them (18%) had significant fibrosis (≥8.2 kPA) by TE at the time of PBC diagnosis. Conclusion: Two-thirds of the incidental AMA-M2-positive patients devel oped typical features of PBC after a median 27-month follow-up. Our re sults suggest that AMA-M2 patients should be closely followed up to detect the late development of PBC