Akademik Veri Yönetim Sistemi
AICMES 9TH INTERNATIONAL CONFERENCE ON SCIENTIFIC STUDIES Jan 16 - 23, 2026 – Mecca , Makkah, Suudi Arabistan, 16 - 23 Ocak 2026, ss.265, (Özet Bildiri)
Isatin is a heterocyclic compound containing an indole core with two carbonyl groups at the 2- and 3-positions. It was first isolated in 1841 from the oxidation of indigo. Its molecular formula is C₈H₅NO₂. Owing to its versatile chemical reactivity, isatin serves as an important scaffold for the synthesis of a wide range of bioactive derivatives. Multicomponent reactions constitute an important part of synthetic organic chemistry due to their advantages such as short reaction times and high yields. These reactions have become frequently used methods in drug discovery studies, particularly because they allow the facile synthesis of biologically active organic molecules containing diverse functional groups. Heterocyclic systems are fundamental structural motifs found in many bioactive compounds. Among these, nitrogen-containing heterocycles have attracted considerable scientific interest owing to their wide range of applications. The uses of such compounds include explosives, lubricants, pesticides, and especially chemotherapeutic agents. From a medicinal chemistry perspective, azoles represent one of the most widely employed classes of antimicrobial agents, mainly due to their high therapeutic efficacy and favorable safety profiles. In this study, the synthesis of several new isatin-containing hybrid compounds, which represent an important class of molecules with broad applications in both organic synthesis and biological sciences, was carried out, and their inhibitory activities against urease and acetyl choline esterase (AcHE) enzymes were investigated. The synthetic studies were performed using both microwave-assisted and conventional methods, and a comparative evaluation will be conducted in terms of yield, reaction time, and purity. In addition, the biological activity results will be analyzed with respect to the effects of substituents attached to the isatin scaffold, and structure–activity relationship (SAR) studies will also be undertaken.