Novel Phthalocyanines Containing Guaiacol Azo Dyes: Synhthesis, Antioxidant, Antibacterial, and Anticancer Activity

KANTAR C., Kaya B., Turk M., Sasmaz S.

JOURNAL OF STRUCTURAL CHEMISTRY, vol.59, no.5, pp.1241-1250, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 5
  • Publication Date: 2018
  • Doi Number: 10.1134/s0022476618050335
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1241-1250
  • Keywords: phthalocyanine, azo dyes, antibacterial, antioxidant, anticancer, METALLOPHTHALOCYANINES, INHIBITORS, METALS, ZINC
  • Recep Tayyip Erdoğan University Affiliated: Yes


In an attempt to understand the antibacterial, antioxidant, and anticancer properties of phthalocyanines containing azo dye, new metallophthalocyanines (M: Mn, Co, Zn) substituted with guaiacol azo dyes are described. The high DPPH scavenging and ferrous ion chelating activity are obtained from almost all compounds. All compounds exhibit a poor antibacterial activity against the studied bacteria. Cytotoxicity, apoptotic and necrotic effects are examined on human breast cancer cells (MCF-7) and fibroblast cells. It is determined that methoxy groups at newly synthesized compounds increase the antioxidant property but decrease other antibacterial and anticancer properties.