Akademik Veri Yönetim Sistemi
49th FEBS Congress, İstanbul, Türkiye, 5 - 09 Temmuz 2025, cilt.15, ss.258, (Özet Bildiri)
Head and neck cancers are a major cause of morbidity and mortality. In recent years, the role of systemic inflammation in tumor development and metastasis has received increasing attention, and hematological inflammatory markers have been considered as prognostic factors in head and neck cancers. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) are simple indicators of systemic inflammation and have prognostic significance in many solid tumors In this study, the efficacy of NLR, PLR, and SII in predicting survival in patients with non laryngeal head and neck tumors was evaluated. SII, NLR and PLR were calculated from preoperative hemogram tests. Cox regression analyses and Kaplan-Meier survival analyses were performed. A total of 45 patients were included in the study. The distribution of tumor localization was as follows: oral cavity (48.5%), lips (21.2%), skin (15.2%), oropharynx (9.1%) and parotid (6.1%). In multivariate analysis, the only variable independently associated with survival was perinodal spread (HR=14.037; p<0.001). The effect of NLR, PLR and SII values on survival was not statistically significant. This study evaluated prognostic factors related to survival in non-laryngeal head and neck tumors. The findings suggest that perinodal spread is an independent prognostic factor for survival. NLR, PLR and SII did not have a significant effect on survival, which may be due to the small number of patients, the stage of the patients, the pathological characteristics of the tumor and the lack of knowledge about whether the patients received preoperative treatment. In conclusion, it is suggested that treatment strategies for patients with perinodal spread should be planned more aggressively.