Melatonin causes regression of endometriotic implants in rats by modulating angiogenesis, tissue levels of antioxidants and matrix metalloproteinases


Yilmaz B., Kilic S., Aksakal O., Ertas I. E., Tanrisever G. G., BAYAZIT Y., ...More

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol.292, no.1, pp.209-216, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 292 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1007/s00404-014-3599-4
  • Journal Name: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.209-216
  • Keywords: Melatonin, Rat endometriosis, SOD, MDA, VEGF, MMP-9, TIMP-2, ENDOTHELIAL GROWTH-FACTOR, ESTROGEN-RECEPTOR, EXPRESSION, EXPLANTS, MODEL, ESTABLISHMENT, PROTECTION, INHIBITORS, PROTEIN
  • Recep Tayyip Erdoğan University Affiliated: No

Abstract

Purpose The aim of this study was to test if melatonin causes regression of endometriotic implants and whether it influences implant levels of superoxide dismutase (SOD), malondialdehyde (MDA), vascular endothelial growth factor (VEGF), tissue inhibitor of metalloproteinase (TIMP)-2 and matrix metalloproteinase (MMP)-9 in rats.