Melatonin causes regression of endometriotic implants in rats by modulating angiogenesis, tissue levels of antioxidants and matrix metalloproteinases

Yilmaz, BÜLENT; Kilic, Sevtap; Aksakal, Orhan; Ertas, Ibrahim; Tanrisever, Gonca; BAYAZIT, YASEMİN; Lortlar, Nese; Kelekci, Sefa; Gungor, Tayfun

doi:10.1007/s00404-014-3599-4

Melatonin causes regression of endometriotic implants in rats by modulating angiogenesis, tissue levels of antioxidants and matrix metalloproteinases

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Yilmaz B., Kilic S., Aksakal O., Ertas I. E., Tanrisever G. G., BAYAZIT Y., ...More

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol.292, no.1, pp.209-216, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 292 Issue: 1
Publication Date: 2015
Doi Number: 10.1007/s00404-014-3599-4
Journal Name: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.209-216
Keywords: Melatonin, Rat endometriosis, SOD, MDA, VEGF, MMP-9, TIMP-2, ENDOTHELIAL GROWTH-FACTOR, ESTROGEN-RECEPTOR, EXPRESSION, EXPLANTS, MODEL, ESTABLISHMENT, PROTECTION, INHIBITORS, PROTEIN
Recep Tayyip Erdoğan University Affiliated: No

Abstract

Purpose The aim of this study was to test if melatonin causes regression of endometriotic implants and whether it influences implant levels of superoxide dismutase (SOD), malondialdehyde (MDA), vascular endothelial growth factor (VEGF), tissue inhibitor of metalloproteinase (TIMP)-2 and matrix metalloproteinase (MMP)-9 in rats.