Novel Microwave Assisted Synthesis and Antimicrobial Activity of New Quinolone-Hybrids

CEYLAN Ş., BAYRAK H., Ozdemir S. B., Uygun Y., Mermer A., DEMİRBAŞ N., ...More

LETTERS IN ORGANIC CHEMISTRY, vol.13, no.9, pp.636-651, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 9
  • Publication Date: 2016
  • Doi Number: 10.2174/1570178613666160927125221
  • Journal Name: LETTERS IN ORGANIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.636-651
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Background: Carbo(thio)amid derivatives 4a, 4b were obtained starting from nalidixic acid in three steps. The acidic treatment of compound 4a generated the corresponding 1,3,4-oxadiazole (5), while the compound 4a gave 1,2,4-triazole derivatives 8a, 8b in basic media. The condensation of 4a with ethyl bromoacetate and 4-chlorophenacyl bromide afforded 1,3-oxazolidine, 6 and 1,3-thiazolidine, 7 derivatives. The synthesis of Mannich bases of 9-15 and 17-19 were achieved from the reaction of 1,2,4-triazoles, 8a, 8b and 1,3,4-oxadiazole, 16, with several heterocyclic amines that has biological activity.