Novel Microwave Assisted Synthesis and Antimicrobial Activity of New Quinolone-Hybrids


CEYLAN Ş., BAYRAK H., Ozdemir S. B. , Uygun Y., Mermer A., DEMİRBAŞ N., ...Daha Fazla

LETTERS IN ORGANIC CHEMISTRY, cilt.13, ss.636-651, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 13 Konu: 9
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2174/1570178613666160927125221
  • Dergi Adı: LETTERS IN ORGANIC CHEMISTRY
  • Sayfa Sayıları: ss.636-651

Özet

Background: Carbo(thio)amid derivatives 4a, 4b were obtained starting from nalidixic acid in three steps. The acidic treatment of compound 4a generated the corresponding 1,3,4-oxadiazole (5), while the compound 4a gave 1,2,4-triazole derivatives 8a, 8b in basic media. The condensation of 4a with ethyl bromoacetate and 4-chlorophenacyl bromide afforded 1,3-oxazolidine, 6 and 1,3-thiazolidine, 7 derivatives. The synthesis of Mannich bases of 9-15 and 17-19 were achieved from the reaction of 1,2,4-triazoles, 8a, 8b and 1,3,4-oxadiazole, 16, with several heterocyclic amines that has biological activity.