Cardiac syncope due to pain Report of a case responsive to duloxetine treatment

KAPLAN C., KOCAMAN S. A., DURAKOĞLUGİL M. E., KAYA E., SENOL M. G.

HERZ, cilt.38, sa.6, ss.683-684, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s00059-012-3734-6
  • Dergi Adı: HERZ
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.683-684
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Neurocardiogenic syncope comprises situations triggered by neurological reflexes resulting in abnormal responses of the neurocardiovascular system that cause loss of consciousness. A vast number of clinical conditions may cause this disorder including pain, defecation, micturition, swallowing, cough, sudden fear or excitement, exercise, and long-time standing. Treatment options for syncope prevention are not satisfactory. Several agents were used for pharmacological treatment without success. Selective inhibitors of neuronal norepinephrine transporter (NET) like duloxetine may play a role in neurally mediated syncope by increasing synaptic norepinephrine levels. Therefore, we report the effect of duloxetine in a patient with pain-induced syncope resistant to standard regimens.