Skin picking disorder is not a dermatological disorder and it is a table characterized with picking skin excessively and repetitively, leading to damage in skin tissue. Unlike normal picking behaviour, psychogenic skin picking is repetitive and it can lead to severe damage in the skin and even compli-cations which constitute vital danger. While some patients define frequent but short lasting picking attacks, others define rarer attacks which last a few hours. Skin picking disorder, which is not included in the classification systems up to DSM-5 as a separate diagnosis category, is included as an independent diagnosis in Obsessive Compulsive Disorder and Associated Disorders category in DSM-5. In this study, the treatment of fluoxetine 40 mg/day and olanzapine 10 mg/day in a 35-year-old female patient who admitted to our psychiatry outpatient clinic with obvious open sores on both arms and legs will be presented in the light of literature information.