The Effect of a Single Hemodialysis Session on Pulmonary Functions in Patients with End-Stage Renal Disease

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Yılmaz Kara B., Kara E., Özyurt S., Gümüş A., Karataş M., Özçelik N., ...More

Turkish Journal of Nephrology, vol.30, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30
  • Publication Date: 2021
  • Doi Number: 10.5152/turkjnephrol.2021.21938
  • Journal Name: Turkish Journal of Nephrology
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Keywords: End-stage renal disease, FEF25, FEV1, FEV3, hemodialysis, lung functions, spirometry
  • Recep Tayyip Erdoğan University Affiliated: Yes


Objective: Changes in pulmonary functions have not been thoroughly investigated in patients undergoing hemodialysis (HD). The aim of this study was to determine the effect of a single HD session on pulmonary functions, measured by spirometry, in patients with end-stage renal disease (ESRD) undergoing chronic hemodialysis (CHD) treatment.
Methods: Thirty patients with ESRD who were on CHD treatment for at least 12 months between January 2018 and January 2020 were enrolled. The pre-dialysis and post-dialysis spirometric measurements were recorded by a portable spirometry device.
Results: The mean age and HD vintage of 30 patients (70% male, 20% diabetic, mean BMI: 26.0 ± 4.7 (kg/m2)) were 55.6 ± 11.4 years and 117.6 ± 66.3 months, respectively. Half of the patients (50%) were smokers (mean 11.5 ± 13.59 packs/year). The spirometric measurements of most of the patients were abnormal (40% restrictive, 30% obstructive respiratory disorder, 30% normal). The FEV3(L), predicted FEV1(%), FEF25(L), and predicted FEF25(%) values were significantly increased after the HD session. A positive correlation between BMI and Delta FEV3 (L) values (r = 0.377, P = .04) was observed. A significant improvement in FEV3 values after a single HD session was recorded, which was independently related to higher BMI (β = 0.501, P < .01) and non-smoking (β = 0.495, P < .05).
Conclusion: Spirometric measurements are abnormal in most CHD patients, and a considerable improvement in pulmonary functions is possible with a single HD session. Having a high BMI and being a non-smoker appear to have significant positive effects on amelioration in FEV3 (L). Larger trials are needed to evaluate pulmonary functions in CHD patients.