An efficient microwave-assisted synthesis of novel quinolone-triazole and conazole-triazole hybrid derivatives as antimicrobial and anticancer agents


Cebeci Y. U. , CEYLAN Ş., ALPAY KARAOĞLU Ş., ALTUN M.

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2022 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1002/jhet.4560
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chemical Abstracts Core, Chimica, EMBASE

Abstract

1,2,4-Triazole-fluoroquinolone and 1,2,4-triazole-conazole hybrids are designed, synthesized, and investigated in vitro against a variety of common diseases. The structure of the newly synthesized compounds are characterized from spectral data (IR, H-1 NMR, C-13 NMR, and LC-MS). The antibacterial activity against both Gram-positive and Gram-negative bacteria is shown to be enhanced by many of the produced compounds. Also, some of the products are found to have strong antiproliferative effects aganist HeLa cervical cancer cells, whilst demonstrating cytotoxic effects toward normal cells.