4-(4-(( 5-Amino-1,3,4-thiadiazol-2-yl)methoxy) phenyl)-1-(( 5-amino-1,3,4-thiadiazol-2-yl)methyl)-3-benzyl-1H-1,2,4-triazol-5( H)-one: Synthesis, Characterization and Computational Studies


Unluer D., ÜNVER Y., Dugdu E., Akcay H. T., SANCAK K.

LETTERS IN ORGANIC CHEMISTRY, vol.13, no.8, pp.604-617, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 8
  • Publication Date: 2016
  • Doi Number: 10.2174/1570178613666160930121719
  • Journal Name: LETTERS IN ORGANIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.604-617
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Background: 1,2,4-triazole and its derivatives are known to have various biological activities such as antifungal, antiviral, antidepressant, antitumor, anti-inflammatory, antitubercular, antimigrain and anti-cancer. Computational chemistry plays an important role in determining structural and chemical properties of chemical compounds. There are many studies on computational studies of triazole derivatives. The aim of this study is to prepare new triazole derivative having potent of bio-active material and to investigate the computational properties.