Axillary-subclavian vein thrombosis or Paget-Schroetter syndrome is an uncommon deep vein thrombosis usually caused by excessive and repetitive upper limb activity. It may cause post-trombotic syndrome, leading to a significant disability, unless treated early and properly. It is most often the consequence of a chronic compression of the subclavian vein at the level of the thoracic outlet. In this article, we present a 24-year-old male case with complaints of swelling, tightness, heaviness in the right half of his neck, upper arm, and right precordial area after repetitive exercises. No etiological factors such as trauma, venous catheter intervention, malignancy, hematologic disorder, or history of any chronic disease were described. Venous Doppler ultrasound revealed subdavian-axillary vein thrombosis. With early thrombolytic therapy, the symptoms relieved and venous patency was maintained.