Akademik Veri Yönetim Sistemi
DIAGNOSTICS, cilt.16, sa.9, 2026 (SCI-Expanded, Scopus)
Background/Objectives:The relationship between P-wave dispersion (Pd) and diseasestatus in patients with Familial Mediterranean Fever (FMF) undergoing colchicine treat-ment is unclear in the literature, and results are contradictory. This study aimed to evaluateP-wave dispersion in patients with Familial Mediterranean Fever receiving regular long-term colchicine treatment and to compare these findings with those of age- and sex-matchedindividuals without FMF.Methods:A cross-sectional and observational study included97 individuals with positive FMF and 97 individuals with negative FMF. FMF diagnosiswas confirmed according to the Tel-HaShomer criteria, and all patients received regularcolchicine treatment and were evaluated during the attack-free period. P maximum, Pminimum, and Pd were measured using standard 12-lead electrocardiography (ECG);clinical, laboratory, and drug data were recorded. Pd associations were analyzed usingcorrelation and multivariable regression.Results:Pd was found to be significantly higherin FMF (+) patients (47 vs. 39 ms,p< 0.001). Pd showed a positive correlation withFMF status (r = 0.508,p< 0.001), colchicine dose (r = 0.476,p< 0.001), white blood cell(WBC) (r = 0.209,p= 0.005) and high-density lipoprotein cholesterol (HDL-C) (r = 0.156,p= 0.037) and a negative correlation with calcium channel blocker use (r =-0.245,p= 0.001). In multivariate analysis, FMF increased Pd by 10.17 ms, while calcium channelblockers decreased it by 11.78 ms (p< 0.001). Age, WBC and HDL-C also had independentpositive effects on Pd (p< 0.001,p= 0.017,p= 0.040, respectively).Conclusions:Thesefindings suggest that FMF is associated with increased P-wave dispersion despite regularcolchicine treatment, indicating persistent subclinical atrial conduction heterogeneity.