Microwave-assisted preparation of azachalcones and their N-alkyl derivatives with antimicrobial activities

Usta A., Ozturk E., Beris F. Ş.

NATURAL PRODUCT RESEARCH, vol.28, no.7, pp.483-487, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 7
  • Publication Date: 2014
  • Doi Number: 10.1080/14786419.2013.879472
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.483-487
  • Keywords: microwave synthesis, azachalcone, antimicrobial activities, N-alkyl azachalconium bromide, CHALCONES
  • Recep Tayyip Erdoğan University Affiliated: Yes


Two new azachalcones were prepared by both Claisen-Schmidt condensation and a simple environmentally trendy microwave-assisted method. Ten new N-alkyl (C-6,C-8,C-10,C-12,C-14)-substituted azachalconium bromides (3a-e, 4a-e) were prepared from compounds 1 and 2 with corresponding alkyl halides. The antimicrobial activities of all the compounds were tested against Enterococcus faecalis, Yersinia pseudotuberculosis, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus micro-organisms.