The effects of TNF-alpha inhibitors on carbon tetrachloride-induced nephrotoxicity

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Ozdemir A., Tumkaya L., Kalcan S., Uyan M., Karakaya A., Demiral G., ...More

CLINICAL AND EXPERIMENTAL HYPERTENSION, vol.44, no.3, pp.291-296, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.1080/10641963.2021.2018600
  • Journal Name: CLINICAL AND EXPERIMENTAL HYPERTENSION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.291-296
  • Keywords: Cleaved caspase-3, kidney, serum BUN, serum creatinine TNF-alpha inhibitors, TNF-beta, INFLIXIMAB, KIDNEY, INJURY
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Objectives: Carbon tetrachloride (CCl4), employed in various industrial fields, can cause acute damage in renal tissues. This study investigated the therapeutic effect of the TNF-alpha inhibitor Infliximab on TGF-beta and apoptosis caused by acute kidney image induced by CCl4.