Akademik Veri Yönetim Sistemi
NATURAL PRODUCT RESEARCH, 2025 (SCI-Expanded)
In this study, activity-guided isolation of the endemic Gelasia sericea (Aucher ex DC.) Zaika, Sukhor. & N.Kilian yielded five new compounds (8-O-beta-D-glucopyranosyl-6-hydroxy-3-(4-hydroxyphenyl)-1H-isochromen-1-one (1), rel. (3 R,3 ' S)-8,8'-oxybis[6-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-isochromen-1-one] (2), 3-O-(4-O-glyceryl)-alpha-D-xylopyranosyl-5-methyl-4H-pyran-4-one (3), 2-carboxyl-3-hydroxy-4 '-methoxy-5-O-(3-O-glyceryl)-beta-D-xylopyranosylbibenzyl (4), and 2-carboxyl-3,4'-dihydroxy-5-O-(beta-D-apiofuranosyl)-(1 -> 6)-beta-D-glucopyranosylbibenzyl (5). Five known compounds as p-coumaric acid (6), scorzopigmecosite (7), scorzocreticin (8), quercetin (9), and kelampayoside A (10). Spectroscopic methods were used to characterise the structures of compounds 1-10. All the isolated compounds, except compound 10, exhibited an inhibition zone diameter of 10-12 mm against at least one of the nine different microorganisms tested. Compound 8 was found to be the most effective with an MIC value of 12.5 mu g/mL against Pseudomonas aeruginosa. Additionally, molecular docking analysis of compounds 1-10 was performed, targeting P. aeruginosa RhlR and DNA gyrase B enzymes. Among the identified compounds, compound 2 exhibited the most promising inhibitory activity against both targets, with binding energies of -12.0 and -11.3 kcal/mol, respectively.