Epithelioid trophoblastic tumor in a postmenopausal woman: A case report and review of the literature in the postmenopausal group

Yigit S., Gun E., Yilmaz B., Kolsuz Z.

INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, vol.63, pp.98-101, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 63
  • Publication Date: 2020
  • Doi Number: 10.4103/ijpm.ijpm_656_18
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.98-101
  • Keywords: Epithelioid trophoblastic tumor, postmenopause, uterus, NEOPLASM, EMPHASIS
  • Recep Tayyip Erdoğan University Affiliated: No


Epithelioid trophoblastic tumor is a rare gestational trophoblastic neoplasm arising from the intermediate trophoblasts. Although usually seen in the reproductive period, it may be encountered during the postmenopausal period. A 56-year-old woman who had given her last birth 21 years ago presented to the hospital with a complaint of postmenopausal bleeding. She had a history of eight live pregnancies and had been in menopause for 4 years. With the help of typical histopathologic and immunohistochemical findings, a diagnosis of "epithelioid trophoblastic tumor" was made. The diagnosis was made at an advanced age and the case had extraordinary features such as high mitotic activity and Ki-67 proliferation index (70%). Gestational trophoblastic neoplasms are rare causes of postmenopausal bleeding which may cause differential diagnosis problem. They should be kept in mind even if the patient age does not comply with because of the differences in treatment.