Akademik Veri Yönetim Sistemi
Allergologia et Immunopathologia, cilt.54, sa.2, ss.10-21, 2026 (SCI-Expanded, Scopus)
Background: Hereditary angioedema (HAE) is a genetic disorder characterized by recurrent, spontaneous, and sometimes life-threatening episodes of swelling. Attacks of angioedema that negatively impact quality of life can occur anywhere in the body. The chronic and unpredictable course of the disease can also affect mental health, sleep quality, and sexual life. Objective: This study aimed to investigate sexual function, sleep quality, and related factors in HAE patients. Material and Methods: In all, 40 patients diagnosed with type 1 and type 2 HAE were followed up in the Immunology and Allergy Clinic, and 40 healthy controls were included in the study. Participants completed the Arizona Sexual Experience Scale (ASEX), Pittsburgh Sleep Quality Index (PSQI), and Hospital Anxiety and Depression Scale (HADS). Results: The patient group had significantly higher ASEX and PSQI scores compared to the healthy control group. In the patient group, ASEX scores showed a significant positive correlation with HADS-Depression (HADS-D) and HADS-Anxiety (HADS-A) scores. It was shown that as frequency of monthly attacks in patients increased, both HADS-D and HADS-A scores increased, and with increase in HADS-D scores, sleep efficiency decreased. Furthermore, a strong positive correlation was shown between HADS-A scores and PSQI scores. Longer disease duration, history of genital attacks, and decreased sleep quality were found to be significantly correlated with sexual dysfunction. Conclusion: The results supported our hypothesis that sexual life and sleep quality are more affected in this patient group than known previously. It is expected that evaluating sexual life, sleep quality, and general well-being in the routine follow-up of these patients may contribute to disease control.