1,2,4-Triazole-conjugated Fluoroquinolones as Potential Candidates for New Antibacterial Agents

Cebeci Y. U., Alpay Karaoğlu Ş.

Letters in Organic Chemistry, cilt.21, sa.8, ss.669-676, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 8
  • Basım Tarihi: 2024
  • Doi Numarası: 10.2174/0115701786270260231215101046
  • Dergi Adı: Letters in Organic Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
  • Sayfa Sayıları: ss.669-676
  • Anahtar Kelimeler: antibacterial, Fluoroquinolones, hybride molecule, mannich base, schiff base, triazole
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

In this study, synthesis of 1,2,4 triazole-fluoroquinolone hybrid compounds was realized. 7a-d hybrid compound was obtained as a result of mannich reaction with 6a-b triazole compounds norfloxacin and ciprofloxacin. 1H-NMR, 13C-NMR, Mass Spectrometry and Elemental Analysis confirmed the structures of all synthesized compounds. The antimicrobial activities of all compounds were investigated, and it was observed that 7a-d compounds, which are mannich bases, showed excellent activity.