ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, vol.27, no.6, pp.715-720, 2018 (SCI-Expanded)
Article / Article
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
Science Citation Index Expanded (SCI-EXPANDED), Scopus
adalimumab, methotrexate, pancreas, rat, toxicity, RHEUMATOID-ARTHRITIS, INSULIN-RELEASE, MODEL, AMINOGUANIDINE, INFLIXIMAB, EXPRESSION, GLUCAGON, RECEPTOR, THERAPY, CELLS
Recep Tayyip Erdoğan University Affiliated:
Background. Methotrexate (MTX), a folate antagonist, is commonly used in the treatment of many different types of cancer and inflammatory diseases, including pancreatic cancer, although its side effects on the pancreas have not yet been researched. The mechanism of MTX-induced toxicity is not well known, and it has been reported in high-dose toxicity studies that the pancreas is sensitive to toxic effects.