ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, vol.27, no.6, pp.715-720, 2018 (Journal Indexed in SCI)
Article / Article
Title of Journal :
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
adalimumab, methotrexate, pancreas, rat, toxicity, RHEUMATOID-ARTHRITIS, INSULIN-RELEASE, MODEL, AMINOGUANIDINE, INFLIXIMAB, EXPRESSION, GLUCAGON, RECEPTOR, THERAPY, CELLS
Background. Methotrexate (MTX), a folate antagonist, is commonly used in the treatment of many different types of cancer and inflammatory diseases, including pancreatic cancer, although its side effects on the pancreas have not yet been researched. The mechanism of MTX-induced toxicity is not well known, and it has been reported in high-dose toxicity studies that the pancreas is sensitive to toxic effects.