Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity

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Mercantepe T., Kalkan Y., Tumkaya L., Sehitoglu I., Mercantepe F., YILDIRMIŞ S.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, vol.27, no.6, pp.715-720, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.17219/acem/68967
  • Journal Name: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.715-720
  • Keywords: adalimumab, methotrexate, pancreas, rat, toxicity, RHEUMATOID-ARTHRITIS, INSULIN-RELEASE, MODEL, AMINOGUANIDINE, INFLIXIMAB, EXPRESSION, GLUCAGON, RECEPTOR, THERAPY, CELLS
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Background. Methotrexate (MTX), a folate antagonist, is commonly used in the treatment of many different types of cancer and inflammatory diseases, including pancreatic cancer, although its side effects on the pancreas have not yet been researched. The mechanism of MTX-induced toxicity is not well known, and it has been reported in high-dose toxicity studies that the pancreas is sensitive to toxic effects.