Topiramate has protective effect on renal injury

Cure M. C., Cure E., TÜMKAYA L., Kalkan Y., Aydin I., Kirbas A., ...More

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.116, no.4, pp.259-263, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 116 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.4149/bll_2015_050
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.259-263
  • Keywords: topiramate, ischemia reperfusion, kidney, carbonic anhydrase II, ISCHEMIA-REPERFUSION INJURY, CARBONIC-ANHYDRASE-III, ANTIEPILEPTIC DRUGS, CELLS, ISCHEMIA/REPERFUSION, ERYTHROPOIETIN, ANTIOXIDANT, INHIBITION
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Background: Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-alpha) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage.