Synthesis and Urease Inhibition Study of Some New Quinazolinone Derivatives Bearing Triazole, Thiadiazole, and Piperazine Moiety

Karaali N., MENTESE M., Baltas N., Mentese E.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.55, no.11, pp.2571-2577, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 11
  • Publication Date: 2018
  • Doi Number: 10.1002/jhet.3313
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2571-2577
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

A new series of 2,3-disubstituted quinazolin-4(3H)-one derivatives bearing triazole and thiadiazole nucleus has been synthesized and then screened for their urease inhibition properties. All synthesized compounds showed outstanding urease inhibitory potentials with IC50 values ranging between 0.25 +/- 0.01 and 18.00 +/- 0.64 mu g/mL when compared with standard inhibitors thiourea (IC50 = 15.08 +/- 0.71 mu g/mL) and acetohydroxamic acid (IC50 = 21.05 +/- 0.96 mu g/mL). All new molecules were characterized by H-1 NMR, C-13 NMR, and MS.