Synthesis and Urease Inhibition Study of Some New Quinazolinone Derivatives Bearing Triazole, Thiadiazole, and Piperazine Moiety


Karaali N. , MENTESE M., Baltas N. , Mentese E.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.55, sa.11, ss.2571-2577, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 55 Konu: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1002/jhet.3313
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Sayfa Sayıları: ss.2571-2577

Özet

A new series of 2,3-disubstituted quinazolin-4(3H)-one derivatives bearing triazole and thiadiazole nucleus has been synthesized and then screened for their urease inhibition properties. All synthesized compounds showed outstanding urease inhibitory potentials with IC50 values ranging between 0.25 +/- 0.01 and 18.00 +/- 0.64 mu g/mL when compared with standard inhibitors thiourea (IC50 = 15.08 +/- 0.71 mu g/mL) and acetohydroxamic acid (IC50 = 21.05 +/- 0.96 mu g/mL). All new molecules were characterized by H-1 NMR, C-13 NMR, and MS.