Clear cell basal cell carcinoma with neuroendocrine differentiation

Leblebici C., Okcu O., Kelten C., Aksu A. E. K.

TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY, vol.50, no.2, pp.73-76, 2016 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.4274/turkderm.01069
  • Journal Name: TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.73-76
  • Keywords: Basal cell carcinoma, neuroendocrine differentiation, clear cell
  • Recep Tayyip Erdoğan University Affiliated: Yes

Abstract

Basal cell carcinomas (BCC) are tumors arising from pluripotent stem cells of the epidermis or hair follicles. There are many histological subtypes such as clear cell, a rare variant, and they have the capacity to differentiate towards distinct directions such as neuroendocrine differentiation (NED). An 81-year-old female patient presented with a mass on the lateral side of the right eyebrow. Excisional biopsy was performed. Histopathologic examination revealed clear cell BCC with prominent rosette-like structures suggesting NED. Immunohistochemically, tumor cells were positive for chromogranin and CD56. This is the first reported case of clear cell basal carcinoma with NED.