Effects of ozone pretreatment on viability of random pattern skin flaps in rats


Öksüz M., Yüce S., Koçak Ö. F. , Canbaz Y., Raʇbetli M. Ç. , Mercantepe T.

Journal of Plastic Surgery and Hand Surgery, vol.49, pp.300-305, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49
  • Publication Date: 2015
  • Doi Number: 10.3109/2000656x.2015.1047452
  • Title of Journal : Journal of Plastic Surgery and Hand Surgery
  • Page Numbers: pp.300-305

Abstract

Background: Medical ozone is a chemical agent that consists of three oxygen atoms and has antioxidant, angiogenic and vasodilator effects. This study evaluated the effects of medical ozone pre-treatment on flap survival. Materials and methods: Rats were divided into four groups of 10 rats each and a 9 x 3 cm McFarlane flap was used. Sham group: Neither surgical nor ozone pretreatment was used. Control group: No pretreatment was used after surgery. Preoperative ozone group: Preoperative 1 mg/kg ozone was given intraperitoneally for 7 days. No pretreatment was used after surgery. Postoperative ozone Group: Postoperative 1 mg/kg ozone was given intraperitoneally for 7 days. After postoperative 1 week, all groups were evaluated by surface area measurement, histopathology and electron microscopy. Results: With the experimental McFarlane flap model, the experimental groups had better surface area measurements, along with histopathological and electron microscopic results when compared with the control group. Conclusion: Medical ozone had positive effects on flap survival due to its antioxidant, angiogenic and vasodilator qualities.